Grazer began his career as a producer developing television projects. While executive-producing TV pilots at Paramount Pictures in the early 1980s, he met current long-time friend and business partner Ron Howard.
He produced his first feature-film, Night Shift, in 1982, directed by Howard. Grazer and Howard teamed up again for Splash in 1984, which Grazer produced and co-wrote. Splash earned him an Oscar nomination for Best Original Screenplay of 1984.
In 1986, Grazer and Howard co-founded Imagine Entertainment, which became one of Hollywood’s most prolific and successful production companies. Over the years, Grazer’s films and TV shows have been nominated for a total of 43 Academy Awards, and 131 Emmys. At the same time, his movies have generated more than $13.5 billion in worldwide theatrical, music, and video grosses.
In 2001, Grazer won an Academy Award for Best Picture for A Beautiful Mind.
In 2015 Grazer published his book A Curious Mind: The Secret to a Bigger Life, in which he discusses conversations with interesting people, many of whom inspired his work.